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This initiates a cascade that leads to the activation of protein kinase A (PKA), closing of potassium channels, depolarization, and release of calcium from the endoplasmic reticulum.3 An increase of intracellular calcium levels within the cell initiates insulin expression in the nucleus, stimulates energy (ATP) production in the mitochondria, and triggers the release of insulin into the blood stream in a glucose dependent manner (image adapted from Adipogen Life Sciences).4,5 Several commercially and prescribed agents are now available for the management of obesity and type 2 diabetes

These include: Nausea : This is the most common side effect, affecting approximately 20-40% of patients initially

And while the official guidance says they are all equivalent, the real-world experience of thousands of researchers tells a more nuanced story

It comprises flavonoids, glycosides, and alkaloids