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Plant GPXLs, containing cysteine in their active site domain, may have dual roles, acting as glutathione peroxidase and thioredoxin peroxidase functions ( 2 O 2 and organic hydroperoxides, as well as their involvement in regulating cellular redox homeostasis by maintaining thiol/disulfide or NADPH/NADP+ ratios ( Deficiency in the activity of either GSH1 or GSH2 impairs GSH production, negatively impacting plant growth and development

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doi:10.1038/cdd.2015.93 Li T, Kon N, Jiang L et al (2012) Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence