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We found that therapeutic doses decrease liver GSH by only modest amounts (10%), but that overdoses of 10 grams or more severely deplete liver GSH (Figure6)
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Intracellular calcium homeostasis and its dysregulation are the basis of seizures, and the prevention of calcium dysregulation due to reperfusion injury may be an effective approach to treat acute symptomatic seizures and reduce the risk of epilepsy after acquired stroke ( 2+ and pH within astrocytes in the hippocampus of animals with epilepsy revealed that all cellular enzyme responses are affected by Ca 2+ and pH and that controlling astrocyte pH and/or Ca 2+ may be a new target for epilepsy therapy or the prevention of epilepsy-related adverse events ( Antiseizure therapy is associated with electrolyte levels
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