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Sweeteners and flavor enhancers confuse gut signals, mess with hormones, and trigger low-level inflammation

Diabetic retinopathy in two patients with congenital IGF-I deficiency (Laron syndrome)

They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain

One example, a GLP-1/gastrin dual agonist developed by Zealand Pharma, is reported to improve glucose control in diabetic mice by improving pancreatic -cell function [226]