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The dissociation of IRP-IRE interaction will promote the translation of ferritin and FPN mRNA and destabilize TfR and DMT1 mRNA, resulting in the decline of iron absorption and increase of iron storage and export [67, 68]

Symptoms of vitamin B12 deficiency include: fatigue, irritability, anxiety, low energy, depression, forgetfulness, constipation, new food sensitivities, hot and cold flashes, sore muscles, pale skin, numbness, tingling, and dermatitis

Answer: Patients often describe subtle changes in the first one to two weeks, more noticeable improvement between weeks two and six, and the most meaningful change by the end of an eight-to-twelve-week protocol