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Incretin mimetics provide a pharmacological stimulus to insulin secretion and elicit other GLP-1-receptor-mediated activity as drugs, but are typically introduced at much higher concentrations compared with physiological levels of GLP-1 [65, 66]

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If this condition is left untreated, gastroparesis could contribute to malnutrition, dehydration, the formation of a bezoar (a solid mass in the stomach), and a host of other health problems

Phase 3 readouts are expected to inform a regulatory submission, though as of early 2026 Retatrutide is not yet approved by the FDA or EMA