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In such cases, second line therapeutics typically consist of biologic DMARDs designed to modulate specific cellular and molecular inflammatory pathways, targeting B cells (anti-CD20 rituximab), pro-inflammatory cytokines (tumor necrosis factor [TNF]- adalimumab) or its receptors (interleukin-6 receptor [IL-6R] tocilizumab), among others (66)

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Your appetite is still high, and cravings are not well controlled If you're frequently hungry or still dealing with strong food cravings, a dose adjustment may help