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In Europe, over half the adult population is overweight, and 17% are clinically obese

Our finding is in agreement with a prospective study reporting that baseline TMAO positively associated with rates of eGFR decline 21 and with studies in animal models of CKD where TMAO diet supplementation increased kidney injury 44,45 and reduced eGFR

If a participant reached a BMI 22 kg/m at any point in the study, the recommended energy intake was to be recalculated

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