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Simultaneously, STAT6 signaling promotes the differentiation of fibroblasts into myofibroblasts and increases apoptosis resistance, reinforcing the pathological survival of fibroblasts within the lesion (Hinz 2010)

In deeply anaesthetised rats (placed in ventral position) the tail was transected with a surgical scalpel 3 cm from the tip (and submerged into a tube with 15 ml of saline at room temperature in vertical position) and the duration and amount of bleeding were measured to evaluate the hemostatic effect of the agents or saline administration