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The most notable known mechanisms [for weight loss] are linked with the central and peripheral nervous systems through direct activation of the hypothalamus and hindbrain or indirect activation via the vagus nerve, resulting in reduced appetite and food intake

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Clinical evidence now supports their use in non-obese individuals with metabolic conditions, with studies showing that semaglutide reduces cardiovascular events by 26% in patients with established heart disease

Another study was carried out by Irizarry et al