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In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)

Restricted to laboratory experimentation and cannot be used in clinical or investigational studies, applied in any medical or therapeutic context, or distributed for purposes outside regulated laboratory research

The glutathione disulfide (GSSG) formed can be recycled to GSH by glutathione reductase in the presence of NADPH

If your research timeline requires more than one vial, store additional unreconstituted vials at 20C and reconstitute them as needed