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All of these effects work together to make GLP-1 drugs very good at controlling blood sugar and helping people lose weight, especially women over 50 who may have trouble with these issues

In pancreatic beta cells, GLP-1RA promotes the conversion of proinsulin to mature insulin by upregulating the expression of hormone converting enzymes PC1/3 and PC2, while reducing the proinsulin/insulin ratio and enhancing insulin biological activity

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