does semaglutide cause suicidal thoughts GLP-1 drugs and ideation: Conflicting studies, small risk FDA Finds No Preliminary Link

Not gradually

doi:10.5334/jcr.190

This includes: Comprehensive medical consultation Review of goals and weight-loss history Metabolic RMR Testing Body Composition Analysis Personalized treatment planning Discussion of medication and dosing options Functional medicine evaluation Review recent labs or order a comprehensive set of personalized labs Required Laboratory Assessment Because Glendale Whole Health practices functional metabolic medicine, baseline laboratory testing is required for all patients entering the program

In an accompanying comment, Nauck and Horowitz (2026) highlight that this study should not be interpreted as demonstrating greater efficacy of orforglipron compared to semaglutide, since similar HbA 1c and weight reductions can be achieved with similar adverse event rates with the (not yet licensed in the UK) 25 mg and 50 mg doses of oral semaglutide (Aroda et al, 2023)