The most parsimonious hypothesis is simply that this is a case of a viral protease targeting a cellular gene for cleavage, for which there are abundant precedents, including the proposed M pro targeting of TRMT1 and HDAC2 (9), and HIV-1 protease, which can be toxic to cells, via its action at various cellular targets (15)
[DOI] [PMC free article] [PubMed] 139.Li Y, Zhang H
Growth is particularly robust in North America and Europe, though the Asia-Pacific region, especially markets like China, Japan, and South Korea, is exhibiting the fastest expansion due to strong cultural emphasis on skin health and advanced aesthetics
198 After hormonal contraception metformin is considered second-line therapy in PCOS, although its effects can be variable