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Proponents argue the Shoemaker Protocol is one of the few treatment frameworks for unexplained multi-symptom illnesses with documented clinical efficacy across multiple peer-reviewed papers

Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial. Lancet 398(10317):21602172

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Specifically, significantly higher amounts of the pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8, have been observed in the amnion and choriodecidua of patients in preterm labor than in women in spontaneous term labor