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Acknowledgements Fang Cao acknowledges all the authors contributions in this manuscript

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2026;6:1004136 DOI: Received: August 17, 2025 Accepted: November 24, 2025 Published: January 04, 2026 Academic Editor: Shile Huang, Louisiana State University Health Science Center, USA Neurodegenerative diseases, including Alzheimers, Parkinsons, Huntingtons, and Amyotrophic Lateral Sclerosis, are characterized by multifactorial pathologies that extend beyond neuronal loss to include neuroinflammation, oxidative stress, mitochondrial dysfunction, and glial dysregulation