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Long-term clinical trials will be needed to address this question

Chen: "GLP-1 therapy can sometimes cause mild nausea, constipation, diarrhea, or fatigue

Other medications and interactions affecting your GLP-1 timeline Many GLP-1 users take other medications or supplements concurrently, and some of these interactions can affect how quickly or effectively the GLP-1 medication works

STEP-4 trial data demonstrated 14% body weight rebound following Wegovy discontinuation at 68 weeks , establishing clinical justification for long-term GLP-1 therapy that insurers and national health technology bodies are progressively incorporating into obesity management protocols