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After being stimulated, neurons of the paraventricular nucleus of the hypothalamus release corticotropin-releasing hormone (CRH), which will be transported by hypothalamic-pituitary portal circulation and stimulate pituitary corticotroph cells to cleave proopiomelanocortin (POMC) in adrenocorticotrophic hormone (ACTH) [12]

Its also unclear why some people experience them while others dont

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