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The structure of both IGF proteins is homologous to human pro-insulin

In preclinical research models, it has been studied extensively for its involvement in angiogenesis (new blood vessel formation), fibroblast activity and collagen synthesis, growth factor modulation (including VEGF and EGF pathways), connective tissue signaling in muscle, tendon, and ligament models, gastrointestinal mucosal integrity, and inflammatory cytokine modulation