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Treatment with GLP-1RA significantly attenuated high glucose-induced tubule damage in DKD kidney tissues and TECs cells ( These findings suggest that both DPP-4i and GLP-1RA elicit pleiotropic tubular protective effects and may serve as another potential therapeutic strategy options to benefit patients with DKD

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Effects outside skin and joints were inconsistent : Some measures of body composition improved, but markers such as blood glucose, cholesterol, and blood pressure showed no clear or reliable changes

Inhibition of vascular cell adhesion molecules An elevation of oxidized low-density lipoprotein (LDL) concentration in plasma has been involved in the pathogenesis of atherosclerosis