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The SELECT trial, published in 2023, enrolled 17,604 adults with overweight or obesity and established cardiovascular disease but without diabetes

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Methods and results We employed a large animal model, the female landrace pig, and used multiple in vivo and ex vivo approaches including pharmacological challenges, electrophysiology, and high-resolution mass spectrometry to explore how GLP-1 elicits an increase in heart rate

L-Carnitine can significantly enhance endurance and exercise performance through: - Enhanced Oxygen Utilization: L-Carnitine improves the bodys ability to utilize oxygen more efficiently, which is essential for sustained physical activity