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Nanoformulations, including nanoparticles, liposomes, micelles, and hydrogels, are designed to target the distinct microenvironment of inflamed joints, which is characterized by leaky vasculature, a mildly acidic pH (~6.0), and elevated reactive oxygen species (ROS), to improve therapeutic efficacy (9)
Alexei Savchenko and Nobuhiko Watanabe at the University of Calgary
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Two areas appear most often in the literature
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