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2018 Jan 1;41(Supplement 1):S7385

[117] Other [edit] Drug patents on semaglutide in Europe and Japan are expected to expire in 2031

(3) Lack of Early Indicators- prior to the cardiovascular outcomes trials (CVOTs), there was no strong evidence or clear biological indicators suggesting that this class of drug would have a direct effect on cardiovascular health

Injection site reactionsincluding erythema, pruritus, or mild painare generally mild and transient but can be minimized through proper injection technique