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Funding This work was supported by grants from The Guangdong Basic and Applied Basic Research Foundation (grant numbers: 2022A1515220187 and 2019A1515111018), National Natural Science Foundation of China (grant number: 82102689), the Excellent Young Researchers Program of the Fifth Affiliated Hospital of Sun Yat-sen University (2023080017 and WYYXQN-2021016), Fundamental Research Funds for the Central Universities of Sun Yat-sen University (grant number: 22qntd3502), the Project of Guiyang Health and Family Planning Commission (grant number: 2018-016), and Yunnan Province Applied Basic Research Program Kunming Medical University Joint Project (202401AY070001-120)

Synthesis Method: Synthesized chemically as a small molecule with peptide-like properties to ensure precise molecular structure and high activity levels

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33 Similarly, Deng et al reported, through a systematic review of 18 studies involving non-diabetic overweight/obese adults, that 86.6% of semaglutide-treated participants achieved 5% weight loss versus 65.3% with liraglutide, reinforcing semaglutides higher efficacy