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Shaking creates mechanical stress that can denature the semaglutide molecule, breaking the structural bonds that give it biological activity
However, as a new approach to enhancing the stability of peptides specifically, and as a part of developing new technologies for the protection and delivery of peptides, the glycosylation strategy, by attaching a sugar moiety to the peptides, is now gaining more attention
However, in patients treated with diclofenac and glucocorticoids, the risk of peptic ulcer and gastrointestinal bleeding may increase, so special attention should be given in case of prolonged treatment, even in the absence of serious gastrointestinal symptoms
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