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What he means is even though melatonin is a hormone that your body naturally produces, taking too much of a melatonin dietary supplement can cause harmful adverse effects

doi: 10.1016/j.neubiorev.2020.03.015

J.TonksN

This theory faces contradictions, such as HPA axis hypofunction being limited to certain patients, no early-stage changes in ME/CFS, and heightened immunosuppressive effects of glucocorticoids in these patients