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Medical consultation becomes necessary when: More than two weeks have passed since the last dose Multiple consecutive doses are missed Severe gastrointestinal symptoms develop Blood sugar levels become difficult to manage Healthcare providers may need to adjust treatment plans, potentially prescribing lower doses to help patients safely resume their medication schedule

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Science (2013) 339(6123):10848

This is consistent with the findings of a meta-analysis of oxidative stress marker abnormalities in children with ASD (147)