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Thus, whereas KEAP1 is a sulfur-utilizing sensor, NRF2 is a sulfur-regulating effector, both together comprising a sulfur-employing defense mechanism

The MAT enzymes encoded by the MAT1A gene function as either homotetramers identified as MAT I (called the alpha form), or as homodimers identified as MAT III (called the beta form)

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks

To gain insight into the underlying mechanisms, we took chemical biological approaches using affinity nanobeads 8 carrying haem and identified progesterone-receptor membrane component 1 (PGRMC1) as a haem-binding protein from mouse liver extracts (Supplementary Fig