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11 Other glucose-lowering treatments can be continued if needed for glycaemic control or cardiovascular or renal protection, with the dose of insulin or a sulfonylurea reduced to prevent hypoglycaemia, if required (see: Prescribing empagliflozin for guidance on dose reduction)

Adverse events were mainly gastrointestinal, and these were more common with orforglipron than with semaglutide ( Table 1 )

Baseline Evaluation Comprehensive metabolic panel Fasting glucose, insulin, A1C Lipid panel (LDL, HDL, triglycerides), advanced lipid markers if indicated