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Klisic A, Kotur-Stevuljevic J, Kavaric N, Martinovic M, Matic M

The purpose of this study was to investigate the regulatory effect and mechanism of TGP on intestinal immunity and epithelial barrier in RA model rats

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For instance, disruption of circadian rhythms by repeated advances in the light-dark schedule in rodent models consistently altered expression of core clock genes such as Per2 and Bmal1, leading to impaired immune function, including reduced NK cell cytotoxicity and decreased expression of cytolytic factors like IFN, perforin, and granzyme B