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Abstract Neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, and other cognitive impairment conditions in elderly are defined by progressive loss of neurons, based mostly on oxidative stress, long-term neuroinflammation, and compromised neuroplasticity

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Here, we investigated the efficacy of tirzepatide (TIR), an antidiabetic agent that improve cognitive function in diabetic rats, in alleviating cognitive impairment in DXN-treated rats