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Patients with MTHFR gene variants experience GI side effects more intensely and benefit from methylated B vitamin co-supplementation during the adaptation phase

Inflamm Res 74(1):81 Taghizadeh M, Maleki MH, Vakili O, Tavakoli R, Zarei P, Dehghanian A, Bordbar H, Shafiee SM (2024) Bilirubin, a hepatoprotective agent that activates SIRT1, PGC-1, and PPAR-, while inhibiting NF-B in rats with metabolic-associated fatty liver disease

While highly effective, the need for weekly injections can be a deterrent for some individuals due to needle aversion or simply the inconvenience of administration

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