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Acquired deficiencies due to liver disease or vitamin K deficiency also impair clotting cascade proteins and increase bleeding tendency

The SUSTAIN-6 study [20], which evaluated the long-term cardiovascular effects of semaglutide sc., in subjects with type 2 diabetes and HbA1c 7%, treated with up to two oral hypoglycaemic agents, with or without basal or premixed insulin, [n = 3297 patients, 50 years with established cardiovascular disease (coronary event, cerebrovascular event, or peripheral vascular disease), chronic kidney disease stage 3, or New York Heart Association class II or III chronic heart failure or 60 years with at least one CVRF)], found a significant reduction in the primary endpoint of MACE appearance by 26% (6.6% vs

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