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BPC-157, by contrast, operates largely through modulation of the nitric oxide (NO) system and upregulation of growth factor expression, including VEGF and EGF, supporting angiogenesis and granulation tissue formation

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TB-500 / thymosin -4s role as a regulator of actin polymerisation in living cells was shown by Sanders and colleagues ( Proceedings of the National Academy of Sciences , 1992), and its broader regenerative biochemistry is reviewed by Goldstein and colleagues ( Expert Opinion on Biological Therapy , 2012)