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56 A study that followed 1,186 Graves disease patients for 610 years found more than half of those initially treated with anti-thyroid drugs later required thyroid-ablative treatment, and only 40% achieved normal thyroid hormone levels without thyroid hormone replacement therapy by the end of the study

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A metric we need to think about is days spent in danger. If intermittent semaglutide use (say, after a period of consistent use leading to measurably improved health status) eliminates the days spent in the danger zone, itll be cost and life saving

A systematic review and meta-analysis published in PMC found that cagrilintide actually had the lowest odds ratio for nausea, vomiting, and diarrhea compared to other incretin-based therapies