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Despite marketing claims and social media comparisons labeling berberine as "nature's Ozempic," there is no credible scientific evidence that berberine directly binds to or activates GLP-1 receptors

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019) Mitophagy inhibits amyloid- and tau pathology and reverses cognitive deficits in models of Alzheimers disease

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If resistance is felt, gently relieve the vacuum with an empty syringe before adding BAC water