[1] The FDA labeling explicitly states that semaglutide should not be administered intravenously or intramuscularly, as these routes were not studied in clinical trials
They are also contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, based on preclinical findings in rodent models
Research indicates that in order to preserve muscle, protein requirements could be above the standard 0.8 grams per kilogram per day
Contact your GP or prescribing clinician if : Leg cramps are severe, persistent, or worsening despite hydration and dietary adjustments You experience difficulty walking or performing daily activities due to cramping or muscle pain Cramps are associated with other concerning symptoms such as dizziness or palpitations Seek urgent same-day medical assessment if : Cramps are accompanied by significant muscle weakness, swelling, redness, or warmth in one leg, which could indicate deep vein thrombosis (DVT) You experience numbness, tingling, or loss of sensation in your legs, which may suggest nerve involvement Call 999 or go to A&E immediately if : You develop chest pain or sudden shortness of breath (possible pulmonary embolism) You have severe, persistent abdominal pain radiating to the back, with nausea and vomiting (possible pancreatitis) Your GP may wish to perform a clinical assessment and arrange investigations, such as blood tests to check electrolyte levels (sodium, potassium, magnesium, calcium), renal function, and thyroid function, as abnormalities in these areas can contribute to muscle cramps
