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Also, the peroxidase (POD) activity was significantly affected by the experimental treatments in both shoot and root of canola plants (Fig

We previously demonstrated that nestin-positive BM stem/stromal cells (BMSCs) provide antioxidant molecules (mainly glutathione, GSH), energy sources (mitochondria), and metabolites, mostly from the tricarboxylic acid (TCA) cycle, driving LSC metabolic adaptation and chemoresistance

Combining pulldown experiments and functional assays to identify senolytic targets To identify the targets responsible for their senolytic activity, we synthesized two alkynylated derivatives of each compound, which we used to perform target identification in competitive, protein-directed activity-based protein profiling (ABPP) experiments (Fig