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K.KirisitsM
Identification of UNC10415667, a benzaldehyde containing NSD2 degrader While UNC10088 and UNC8732 are promising cell-free and cell-based tool compounds, respectively, we were interested in developing non-prodrug analogs that could similarly engage FBXO22 to promote NSD2 degradation without requiring bioactivation for activity
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Theres no plateau. HU6 is currently being investigated in a Phase IIa study for obese patients with heart failure with preserved ejection fraction (HFpEF) and a Phase IIb study for patients with metabolic dysfunction-associated steatohepatitis
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