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School of Public Health, and Director of the Child and Adolescent Population Health Program at UT Southwestern

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Prescription anti-emetics such as ondansetron can be used short-term under provider supervision, though metoclopramide should be avoided long-term due to neurological risks

It should not be used by people who: Have a personal or family history of medullary thyroid carcinoma Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Have a known allergy or hypersensitivity to orforglipron or any of the components of the tablet Are pregnant, planning pregnancy in the near future, or breastfeeding Are already using another GLP-1 receptor agonist (combining them is not recommended) Caution is also advised in patients with a history of pancreatitis, gallbladder disease, severe gastrointestinal disease such as gastroparesis, or significant kidney disease