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Metabolic Effects Supported by Clinical Data A meta-analysis of 27 RCTs (N=2,569) published in Medicine found berberine 500 mg three times daily reduced fasting blood glucose by a mean of 19.83 mg/dL and HbA1c by 0.71% compared with placebo or lifestyle control [3]

For someone with healthy kidneys, vitamin C is likely reasonably safe

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The reticulocyte count is increased and may reach peaks of 30% or greater, with an elevated percentage of the immature reticulocyte fraction, reflecting a prompt and effective bone marrow response