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1,2,3 The most common side effects reported in the clinical program included low blood sugar, nausea, stuffy or runny nose and sore throat, diarrhea, upper respiratory tract infection and headache

Inadequate malate oxidation by MDH2 would limit OAA availability for the GOT2 reaction, while malate could be exported from mitochondria via SLC25A10/DIC and SLC25A11/OGC, supporting cytosolic NAD reduction and OAA formation through MDH1, ultimately producing aspartate via GOT1

SGLT2i outperformed metformin in lowering body weight and FPG levels, but both were similarly effective in reducing HbA1c levels