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In such cases, pancreatic enzyme replacement therapy (PERT) may be prescribed under medical supervision, using licensed medicinal products such as pancreatin (e.g., Creon)

But they underscore the importance of careful medical oversight

Patients and clinicians highlighted that early-onset obesity and hyperphagia are 2 of the most distressing symptoms, causing significant caregiver burden and impairment to HRQoL, and that typical obesity management strategies such as restricted diet are less feasible and less sustainable in this population than in general obesity

For comprehensive synergistic support regarding systemic detoxification, clinical nutritionists often recommend pairing NAC with specialized liver-support botanicals like Milk Thistle (Silymarin) or Alpha-Lipoic Acid