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Longer-cycle research (412 weeks) tracks effects on mitochondrial markers, sirtuin activity, and clinical outcome measures

Without lifestyle changes, these medications are likely to be less effective for weight loss

This is often due to lifestyle factors, medication side effects, and the stress brought on by psychiatric illnesses

doi: 10.3389/fphar.2026.1736380 Received 10 November 2025 Revised 20 January 2026 Accepted 21 January 2026 Published 10 February 2026 Volume 17 - 2026 Edited by Madhusudan Prasad Singh, All India Institute of Medical Sciences Raipur, India Reviewed by Hemasri Velmurugan, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), India Prachi Arunima, All India Institute of Medical Sciences Raipur, India Updates Copyright 2026 Wali, Rangraze, Khan, Mufti, El-Tanani and Rizzo