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According to the 2017 Global Burden of Disease (GBD) study, the worldwide number of IBD cases reached 6.8 million, and the age-standardized prevalence increased from 79.5 per 100,000 persons in 1990 to 84.3 per 100,000 in 2017 [3]

In addition, macrophages are capable of producing a variety of inflammatory factors, such as NF-B, TNF-, IL-2, IL-6 and IL-8 and activating nuclear transcription factors like NF-B, which also play an important role in the progression of MASLD (92)

Chapter 8: assessing risk of bias in a randomized trial

Premenopausal women with functioning ovaries typically have enough estrogen production to compensate for the loss from adipose tissue, though exceptions exist, especially with very rapid or very significant weight loss