Since the more mildly-affected participants often responded well to cofactor therapy alone, and that the side effects of the cofactors are generally much less than that of the medications [5 and author's experience], a trial of cofactor and dietary therapy alone may be warranted in most CVS patients encountered in clinical practice, with amitripyline or cyproheptidine added in refractory cases
Topical astaxanthin has been shown to: Protect against UV-induced skin damage Increase moisture retention Reduce fine lines and wrinkles Improve skin tone and elasticity One study published in Carotenoid Science found that astaxanthin applied topically reduced age spots, improved elasticity, and minimized fine lines in participants after just 8 weeks
As the authors explain, these factors are quite important in chronic diseases like diabetes, in which trajectories and therapeutic responses vary
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