glp 1 and resting heart rate Differential effects of glucagon-like peptide-1 receptor agonists on | Cardiovascular Diabetology Heart rate lowered, post GLP-1

They are optimal for their insulinotropic effect exclusively when glucose levels are elevated, thereby providing the capacity to decrease plasma glucose while mitigating the risk of hypoglycemia

ALT and AST levels were significantly elevated in the liver fibrosis group, but there was no statistically significant difference between the treatment group and the liver fibrosis group

However, the safety of these agents in pregnancy is largely unknown, as pregnant women are typically excluded from clinical trials

However, cardiovascular safety trials in type 2 diabetes patients, the majority presenting cardiovascular disease and excess weight, showed that GLP-1 receptor agonists were indeed capable of decreasing cardiovascular risk