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Also, p-cresol is a uremic toxin, found to accumulate in the serum of chronic kidney disease patients [190], revealing deleterious effects on the endothelium in vitro [191, 192], and inducing the formation of EMVs in cultured ECs [193, 194]

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Together, these results reinforce insulin sensitization as a central mechanism underlying Retatrutides investigational relevance in PCOS hyperinsulinemia