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It is particularly beneficial for those with comorbidities such as type 2 diabetes

The 0.25 mg starting dose is intentionally sub-therapeutic for glycaemic control but serves as a tolerance-building phase

4.2 Dysbiotic microbiome stimulates cyclooxygenase-2 expression, affects gastric emptying, and induces GERD Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme that catalyzes the initiating step in the metabolism of arachidonic acid to prostaglandin H2 and is a precursor to prostaglandins such as prostaglandins, thromboxanes, and prostacyclins, which act as autocrine and paracrine lipid mediators in the maintenance of local homeostasis by mediating vascular function, wound healing, and inflammation (52)

Planning balanced meals and regular activity before discontinuation helps prevent sudden weight changes when the medication ends