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FOXO4-DRI is a senolytic peptide a D-retro-inverso peptide engineered to selectively eliminate senescent "zombie" cells that accumulate with age and secrete inflammatory factors (the senescence-associated secretory phenotype, or SASP)

Withaferin A, as a steroid isolated from Withania somnifera , is a natural ferritin inducer for neuroblastoma, dose-dependently either activates the NRF2 pathway through targeting of Kelch-like ECH-associated protein 1 (KEAP1) or aspartate aminotransferase (GPX4) to induce ferroptosis [171, 172]